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Welch Materials

Welch Materials is a fast growing high quality column producer with a large and competitive product range sold around the globe

Welch Material Inc was founded 2003 in Maryland, USA and Shanghai, China by several PhD scientists from top Universities such as MIT and  University of California at Berkeley. They hav extensive experience in  particle surface modification and bonding chemistry.  Through optimal  utilization across two countries, they have developed many innovative  LC and GC consumable products, in particular HPLC and SPE products. 

Attention
Chiral Chromatography Method Development fast and without risk!

Download list of Chiral Compounds, check probability of success of your target compound!

If probability of success is greater than 80% please contact us, we will send you the relevant chiral column  and Method free of charge for evaluation

The product range is structured as follows:

Ultisil XB Range made from spherical, totally porous, and ultra high purity (>99.999%) type B silica particles.  Analytical and prep column

Topsil Product Range (silica based analytical and prep column with the same surface  chemistry as Ultisil XB but with significantly different selectivity.)

Xtimate hybride and polymer Range of HPLC Columns

Welchrom SFE materials

Wide range of very interesting Solid phase Extraction materials

 

Ultisil Columns

Welch manufactures next generation Ultisil® XB series HPLC columns ( sold as Ultimate® XB series until 2010, The trade name Ultimate is now used only in China) for pharmaceuticals, food safety, drug control, environmental, agrochemicals, cosmetics and academic labs

Ultisil® HPLC columns are made from spherical, totally porous, and ultra high  purity (>99.999%) type B silica particles. Our proprietary surface  modification treatment before bonding generates a very smooth and  uniform surface with less acidic surface silanols.

Welch offers a full line of phases including XB-C18, AQ-C18, XB-C8,  XB-Phenyl, and XB-CN to provide a wide range of selectivities. These  phases were developed using state-of-the-art bonding chemistry  technology to provide unique performance characteristics to enable the  most demanding separations. All phases are fully end-capped by  proprietary techniques to ensure excellent peak shapes and long  lifetime. All bonding, end-capping and packing processes are optimized  and well-controlled to achieve maximum efficiency, excellent  batch-to-batch and column-to-column reproducibility, and longer  lifetime. Ultisil® HPLC columns provide the Ultisil  performance in peak shape, efficiency and resolution. Through continuous innovation, Welch Materials offers customers the best tools and  solutions for separation, purification, and analysis of organic and  bio-organic compounds.

Application Data Index (Find your Application of interest and ask for appropriate chromatograms)

Welch_Ultisil_Index_of_Comparison_and_Performance_Data

Ultisil XB Reverse Phase Columns

Ultisil XB - C18 :

  • The most universal C18 column featuring high surface coverage and  exhaustive double end-capping providing optimal separation for basic,  neutral, polar and acidic molecules.
  • Product is sold in mid price range

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-C18

Octadecyl

double

3,5,10

120'200'300

320

1.5-10

17

 

Ultisil XB-C8 :

 

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-C8

Octyl

double

3,5,10

120'200'300

320

1.5-10

17

 

Polar bonded Phase

Ultisil XB-CN :

  • Low hydrophobicity, for rapid elution of hydrophobic molecules
  • Suitable for use both in Reverse and Normal phase mode.
  • Unique selectivity for polar compounds
  • Retention and separation of strongly basic analytes, including quaternary ammonium salts with excellent peak shape
  • Compatibility with highly aqueous mobile phases
  • Exceptional batch to batch and column to column reproducibility
  • Exceptional stability and column life-time, from pH 1.5 to 9.0
  • Available in dimensions from analytical to preparative for all sample sizes

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-CN

 

 

3,5,10

120'200'300

320

 

 

 

Ultisil Silicate

 

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-SiO2

l

 

3,5,10

120'200'300

320

2-8

0

 

Ultisil XB-NH2 :

  • Column is used in Normal phase mostly
  • Propyl-amino silane phase bonded to Ultisil Silica
  • Used for normal phase and weak anion-exchange  and reverse phase HPLC of polar compounds
  • For applications in aggressive normal phase mode with aqueous eluent
  • Vitamin A and D are separated in the normal phase mode  and carbohydrates  and sugars are separated in reverse phase mode

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-NH2

Aminol

 

3,5,10

120'200'300

320

2 -8

8

 

Ultisil XB-Diol :

  • May be used as polar sorbent in normal phase mode
  • Like bare silica XB-Diol has the ability to form hydrogen bonds and to separate structure isomers
  • Since most of its surface is covered with organic functions Ultisil XB-Diol  adsorbs less water, with less or more reproducibility
  • More stable than the traditional normal phase  column, such as silica or amine
  • Could be used in reverse phase
  • Similar polarity to amine
  • Good selectivity without excessive retention
  • Improved peak shape vs. bare sillica

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil XB-Diol

Diol

 

3,5,10

120'200'300

320

2 - 8

8

 

Ion Exchanger Columns

Ultisil SAX :

  • Silica based polar linked strong anion exchanger
  • High resolution because of silica structure and high efficiency
  • Polar bonded phase consisting of ammonium-functionalised silane
  • Organic modifiers such as acetonitrile and methanol may be used with SAX columns within organic / buffer solubility constraints
  • Retention can be controlled by varying pH, ionic strength and organic modifier content
  • Stable from pH 2 to 7

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil SAX

Ammonium functionalised Silane

 

3,5,10

120'200'300

320

2 - 7

 

 

Ultisil SCX :

  • Strong cation exchanger with covalently bonded sulfonic acid moiety
  • High resolution because of silica structure and high efficiency
  • Polar bonded phase consisting of ammonium-functionalised  silane
  • Organic modifiers such as acetonitrile and methanol may be used with SAX columns within organic / buffer solubility constraints
  • Retention can be controlled by varying pH, ionic strength and organic modifier content
  • Stable from pH 2 to 7

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil SCX

aromatic sulfonic acid moiety

 

3,5,10

120'200'300

320

2 - 6.5

 

 

Chiral Phases

Ultisil Chiral :

    There are four types of chiral phases

    1. Chiral AD,

    2. Chiral AS,

    3. Chiral OD

    4. Chiral AJ

  • Based on polymer coated silica
  • 80% of all racemate compounds can be separated by those four columns
  • Chiral AD and Chiral OD is the most used chiral column
  • Excellent resolution of racemats
  • Fast, easy method  development
  • Columns are durable and long lasting
  • Smooth transition from lab to development, pilot and production scale.

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil Chiral

 

 

5,10

120

 

2 - 9

 

 

Polar Embedded HPLC Columns

Ultisil Polar-Embedded RP :

  • Polar embedded silica.
  • Excellent selectivity for polar molecules
  • Polar embedded phases have been developed for more than 10 years. Early  developments where amide phases with problem of phase collaps.
  • Excellent peak shape for polar compounds

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil Polar RP

 

double

3,5,10

120'200'300

320

1.5-10

18

 

Ultisil Phenyl-Ether :

  • As with RP but with C 18 RP
  • Polar embedded silica with phenyl ether groups

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil Phenyl Ether

 

double

3,5,10

120'200'300

320

1.5-10

13

 

Fluorinated Phases

Ultisil PF-Phenyl :

Welch_Ultisil_PF-Phenyl

  • Primarily used for separating fluor containing molecules Ideal for separating fluor containing aromatic molecules.
  • May also be used for separating non fluorous compounds such as Taxol, and  its derivatives because of its aromatic ring it has a higher selectivity compared to other alkyl-fluoronated phases
  • Can separate nitro-benzene isomers (para vs. ortho) which can not be separated by traditional phenyl phase

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil PF Pnenyl

 

double

5

120

320

1.5-10

13

 

Ultisil F-C8 :

  • High  selectivity and retention towards halogenated aromatics and alkyl compounds
  • Just different from octal alkyl phase

Welch_Ultisil_F-C8

 

Analyte Specific Columns

Ultisil PAH :

  • Silica based column for separating Polycyclic Aromatic Hydrocarbon.
  • Optimised for EPA Method 610 in less than 30 min. with high resolution
  • Very good peak shape

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil PAH

 

yes

5

120

320

1.5-10

 

 

Ultisil Amino Acid :

  • Made from spherical totally porous and ultra high purity type B silica particles
  • Proprietary bonding method applied to create smooth surface with less acidic silanol groups on the surface
  • Provide the best performance in peak shape , efficiency  and resolution for the analysis of 18 Amino acids within 30 min.
  • Most amino acids have no absorbance under UV detector, the sample should be derived before HPLC  analysis
  • The package includes:

  • One Amino acid HPLC column
  • Amino acid  bench mark (18 kinds of amino acids)
  • Reagent for derivatisation
  • Amino acid analysis user manual

 

    Download PTIC Method

 

Ultisil C30

  • Compared to classical C18 stationary phases, C30 is much more hydrophobic and  retainable. Even when pure organic eluents is applied, many sample  solutes, for example  carotenoids are able to be retained.
  • Ultisil C30 is designed for the separation of geometric isomer recognition,  polar carotenes, polar and non polar xanthophylls, steroids, retinols  and fat soluble Vitamins (A, D, K and E)
  • Comprises polymeric C30 alkyl chains
  • Very lipophylic
  • Exceptionally selective pattern for geometric isomers

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil C30

 

 

 

 

 

2-6

 

 

Unique Phases

Ultisil LP - C18 :

  • The column for low pH application (pH 1)
  • Comprises of two, very bulky hydrophobic protective groups to prevent siloxane bond from hydrolysis at low pH condition.
  • For use with very low pH eluents (pH 1.0) at high temperature
  • Is the most stable C18 low pH material in the market
  • Because LP is not end-capped and has more surface silanols LP phase has more  retention for some early eluted polar compounds and provides some  different selectivity than traditional C18 phases.
  • LP-C18 is the most polar C18 amongst all of the C18  phases
  • Endures 100% water as the mobile phase
  • Best peak fro polar compound analysis
  • Exceptional lifetime at low pH (1.0 - 8.0)

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil LP C18

Octadecyl

 

3,5,10

120'200'300

320

1- 8

10

 

Ultisil AQ-C18 :

  • Reverse Phase material with high selectivity for polar and hydrophilicity,  which are either not or poorly retained on other phase.
  • A proprietary bonding chemistry avoids phase collaps, even if 100% water is being used.
  • AQ-C18 is fully end-capped to ensure best peak shapes of polar and basic compounds and longer lifetime.
  • Typical applications are separations of biomolecules, metabolites and  pharmaceutical degradants such as organic acids , water soluble  vitamins, oligosaccarides , amino acid small peptides and nucleotides

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Ultisil AQ- C18

Octadecyl

double

3,5,10

120'200'300

320

1.5-10

12

 

Ultisil Amphion

 

 

Xtimate Hybride Reverse Phases/Columns:

Xtimate is the brand-name for Welch premium HPLC column series. There are two types of Xtimate  column, those based on based on Hybride Silica Polymer packing  materials, and those based on pure polymer materials.

Xtimate C18 : Silica coated with 2 nm silane polymer coating and C18 alkyl groups. High mechanical stability

 

Test condition:

  • Ximate C18, 5um,150 x 4.6 mm / Gemini, C18, 5 um, 150 x 4.6 mm
  • Mobile Phase:
      A: 10 mM Ammonium Bicarbonate pH 10.5
      B: 90 :10 Acetonitrile / buffer
  • Gradient:  0% to 100% B in 10 min.
  • 100 % B last min.
  • 0% B last 3 min.
  • Flow:  1.0 mL/min
  • Temp:  50°C
  • Detector:UV @ 254 nm

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate C18

Octadecyl

yes

3,5,10

120'200'300

320

1.0 - 12.5

14

 

Xtimate C8 :

  • Silica hybride with C8 alkylgroups

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate -C8

Octyl

double

3,5,10

120'200'300

320

1- 12.5

10

 

Xtimate C4 :

  • Silica hybride with C4 alkylgroups

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate C4

 

yes

3,5,10

120'200'300

320

1- 12.5

 

 

Xtimate Phenyl-Hexyl :

    Silica hybride with phenyl - hydride moieties

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate Phenyl Hexyl

Phenyl Hexyl

yes

3,5,10

120'200'300

320

1 - 12.5

 

 

 

Xtimate CN :

  • Silicahybride with embedded polar reverse phase groups.

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate Polar RP

 

 

3,5,10

120'200'300

320

1 - 12.5

 

 

Xtimate Saccharide-H :

  • Packed with spherical, low cross linked polystyrene/divinylbenzene PS/DVB   particles of  5 um and 8 um size. The surfaces are modified with  sulfonic acid (-SO3H). The separating mechanism is based on ion-exchange mechanisms.
  • Compatible with most aqueous mobile phases, including pure water as eluent. Wide  operating temperature 20 - 90°C. pH range 1-3 . Analytical and  preparative columns.
  • Used for Ribavirin detection. Ribavirin is an anti-viral drug used by many  hospitals  in the treatment of respiratory syncytial virus infection

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate Saccaride H

 

 

6.8

no pores

 

 

Crosslinking 10%

 

Xtimate Saccharide-Ca :

  • Packed with spherical, low crosslinked polystyrene / divinylbenzene PS/DVB   particles of  5 um and 8 um size. The surfaces are modified with  sulfonic acid (-SO3H ,followed by chelating of calcium ions (Ca2+). The  separating mechanism is based on ion-exchange mechanisms.
  • Compatible with most aqueous mobile phases, including pure water as eluent. Wide  operating temperature 20 - 90°C. pH range 1-3 . Analytical and  preparative columns.
  • Used for analysis of sugar products such as hydrolysis of beet, cane and  starch in streams processing plants . Glucose, fructose, maltose and  maltotriose can be separated from higher oligomers found in typical corn syrups.

Column

Functional Group

Endcapped

Particle size um

Pore Size A

Surface Area m2/g

pH Stability

Carbon Load %

Xtimate Saccaride Ca

 

 

6.8

no pores

 

 

Crosslinking 10%

 

 

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