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Kromasil is a highly recommended, robust, pure silica manufactured by EKA Chemicals AB of Sweden a subsidiary of EKA Noble. It has been designed for analytical and preparative HPLC applications and is available in six particle sizes ranging from 3 to 16 um. Kromasil has a track record in Silica chemistry for more than 60 years and has pioneered many new products.
Kromasil is manufactured using a well known sol-gel technique which gives the resultant silica optimized chemically and mechanical stability, pore structure and reproducible surface.
Development and production of Kromasil packaging are ISO 9001 Certified
LCC is sole distributor of Kromasil for Switzerland since many years.
Kromasil product range comprises of
Kromasil 60, 100 and 300 A
- Spherical porous silica
- Analytical to preparative particle sizes
- Robust and reproducible
- Large surface area
- Competitively priced
- Excellent Batch to batch reproducibility
- Excellent Chemical Stability
- Analytical to prep scale applications
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Kromasil Phase
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Functional Group
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Endcapped
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Particle size um
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Pore size A
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Surface Area m2/g
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Carbon Load %
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Silica
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5,7,10,13, 16
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60
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540
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Silica
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3.5,5,7,10,13, 16
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100
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320
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C1
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Methyl
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Yes
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5
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100
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320
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4.7
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C4
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Butyl
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Yes
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3.5,5,7,10,13, 16
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100
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320
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8.0
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C8
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Octyl
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Yes
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3.5,5,7,10,13, 16
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100
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320
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12
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C18
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Octadecyl
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Yes
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3.5,5,7,10,13, 16
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100
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320
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20
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NH2
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Amino
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no
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3.5,5,7,10,13, 16
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100
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320
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1.7
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CN
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Cyano
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No
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5,10,16
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60
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540
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12
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Diol
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Dihydroxy
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No
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5,10,16
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60
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540
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10
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Phenyl
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Phenyl
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Yes
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5,10,16
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100
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320
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14
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Silica
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5,10,16
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300
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110
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C4
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Butyl
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Yes
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5,10,16
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300
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110
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2.9
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C8
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Octyl
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Yes
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5,10,16
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300
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110
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4.7
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C18
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Octadecyl
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Yes
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5,10,16
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300
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110
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8.7
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Kromasil 300 A Column for Biochromatography
- 300 A spherical silica
- For Biomolecules that are larger than 8 - 10 kDa
- Protein Separation from analytical to process scale
- Narrow pore size distribution ensures good mass transfer for molecules in this range resulting narrow peaks and no size exclusion effects
- High mechanical and chemical stability
- Available in
- Micro-bore (1.0 - 2.1 mm Column
- Analytical
- Semi-prep (7.75 - 10 mm i.d.) Column
- Prep (21.2 to 30 mm id) Column
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Preparative and Process Scale Kromasil
- Scalable, Manufactured in large batches prior fractionation into narrow particle sizes
- Mechanical strength (Have to be packed in columns with large pressures)
- Superior load-ability (high pore volumes and surface area resulting in high load-ability without weakening their mechanical strength
- Technical service
Kromasil Chiral Phases
Benefits:
- Kromasil based silica
- High chemical stability
- High load-ability
- Complementary phase selectivity
- Application booklet
Kromasil DMB and TBB
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Chiral Monomer
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0,0’-bis(3.5-dimethylbenzoyl)-N,N-diallyl-L-tartardiamide
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0,0’-bis(4 tert-butylbenzoyl)-N,N-diallyl-L-tartardiamide
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Particle siz (um)
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5,10
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5,10
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Surface area (m2/g)
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340
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340
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Pore size A
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100
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100
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Carbon load %
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14.5
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15.0
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Nitrogen load %
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0.6
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0.6
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Kromasil_Chiral_Application Guide
Kromasil_Chiral_DMB_and_TBB_Datasheet
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Kromasil AmyCoat & CelluCoat
A new material and new chiral chemistry
Benefits
- Polysaccaride based chiral HPLC
- Analytical and prep application
- No pressure limits, Mechanically strong
- Small particles (3 um)
- High resolution
- Unique coating method
- Wide range of compatible mobile phases
Kromasil_Brochure_AmyCoat
Kromasil_Brochure_CelluCoat
Important Publication (Please ask for copy )
- Important Aspects when Designing Chiral Preparative Separations using Coated Polysaccharide Stationary Phases
- Kromasil AmyCoat, a new Polysaccharide-based Chiral Stationary Phase for Rapid and Efficient Chiral Resolution
- From Screening to Purification, Presentation of a Strategic Approach to Solving Chiral Separation Issues by HPLC
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Kromasil Hybride materials
Benefits
- Small hybride particles (2.5 um)for uHPLC conditions
- Long lasting columns
- Modified silica
- Operation condition pH 1 - 12
- Easier method development
Kromasil Eternity C18 and Kromasil Eternity Phenyl-Hexyl
Kromasil_Eternity_C18
Kromasil Eternity Phenyl Hexyl
Important Publications (Please ask for copy)
- Utility of a chemically stable aromatic stationary phase for HPLC and UHPLC separations at acidic and basic pH
- A new generation of Analytical HPLC products
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